Juan E. Sereno, Ph.D.

Incoming Postdoctoral Researcher at the University of Dubrovnik

We can only see a short distance ahead,

From 1 November 2026 I will join the University of Dubrovnik as a postdoctoral researcher on the Conduction / InterCoML project, working on infinite-dimensional optimal control under the supervision of Prof. dr. Martin Lazar. Until September 2026 I was a postdoctoral research fellow at the University of Idaho, in the Department of Mathematics and Statistical Science, where I worked in the SMID Lab under the supervision of Prof. Esteban A. Hernandez-Vargas.

I obtained my Ph.D. in Mathematical Engineering from the Universidad Nacional del Litoral, Argentina, under the supervision of Prof. Alejandro H. González, with a thesis on predictive controllers for hybrid systems applied to socio-biomedical processes. Before that I completed an M.Sc. in Industrial Automation and a B.E. in Control Engineering at the Universidad Nacional de Colombia.

My work sits between control theory and mathematical biology: model predictive control, adaptive observers, reduced-order modelling and nonlinear mixed-integer optimization, applied to infectious diseases, diabetes and medical digital twins.

I am always glad to discuss research and new collaborations — feel free to get in touch.

news

Oct 25, 2026	Short course “Parameter Monitoring with Adaptive Observers” at Semana IEIC 2026. Slides, step-by-step MATLAB and Python code, Jupyter notebooks and exercises are open on GitHub. [repo]
Oct 25, 2026	Invited talk at Semana IEIC 2026, Facultad de Minas, Universidad Nacional de Colombia, Medellín (26 October 2026): “Observadores adaptativos para gemelos digitales médicos: un marco para la medicina personalizada”. [poster]
Sep 01, 2026	I will join the University of Dubrovnik as a postdoctoral researcher on the Conduction / InterCoML project, starting 1 November 2026.
Jun 16, 2026	Gave the talk “Parameter Inference in Immune Digital Twins: A Stochastic Adaptive Filtering Approach” at Washington State University, Pullman. [slides]
Feb 19, 2026	Presented “Adaptive Observers for Medical Digital Twins: A Framework for Personalized Medicine” at the University of Idaho Mathematics and Statistical Science colloquium. [slides]
Nov 01, 2025	New paper in Frontiers in Applied Mathematics and Statistics: “Iterative calibration of medical digital twins via adaptive estimators”.
Jul 01, 2025	Paper accepted at the 64th IEEE Conference on Decision and Control (CDC), Rio de Janeiro: “Adaptive Observers for Calibrating Immune Digital Twins in Viral Infections”.
Jun 08, 2025	New paper in IEEE Control Systems Letters: “Time-Constrained MPC Approach for Switched Nonlinear Systems”.
Oct 10, 2024	Gave the talk “Understanding SIR-type epidemic behaviors through set-based dynamic analysis” at the University of Idaho. [slides]
Sep 01, 2024	Started as a Postdoctoral Research Fellow at the University of Idaho, SMID Lab.
Apr 01, 2024	Completed my Ph.D. in Mathematical Engineering at the Universidad Nacional del Litoral, Argentina.
Jan 01, 2023	Paper published in Annual Reviews in Control: “Switched NMPC for epidemiological and social-economic control objectives in SIR-type systems”.
Oct 01, 2022	Paper published in Automatica: “Minimizing the epidemic final size while containing the infected peak prevalence in SIR systems”.

latest posts

Jun 20, 2026	Inferring parameters in immune digital twins when the immune system will not sit still
Oct 15, 2024	What set-based analysis tells you about epidemic interventions

selected publications

Frontiers

Iterative calibration of medical digital twins via adaptive estimators

Juan E. Sereno, Havilah Neujahr, Miguel Hernandez-Gonzalez, and 1 more author

Frontiers in Applied Mathematics and Statistics, 2025

DOI Bib

@article{sereno2025iterative,
  title = {Iterative calibration of medical digital twins via adaptive estimators},
  author = {Sereno, Juan E. and Neujahr, Havilah and Hernandez-Gonzalez, Miguel and Hernandez-Vargas, Esteban A.},
  journal = {Frontiers in Applied Mathematics and Statistics},
  volume = {11},
  pages = {1699390},
  year = {2025},
  doi = {10.3389/fams.2025.1699390},
}

IEEE L-CSS

Time-Constrained MPC Approach for Switched Nonlinear Systems With Applications to Biomedical Problems

Juan E. Sereno, A. D’Jorge, Esteban A. Hernandez-Vargas, and 1 more author

IEEE Control Systems Letters, 2025

DOI Bib

@article{sereno2025timeconstrained,
  title = {Time-Constrained {MPC} Approach for Switched Nonlinear Systems With Applications to Biomedical Problems},
  author = {Sereno, Juan E. and D'Jorge, A. and Hernandez-Vargas, Esteban A. and González, Alejandro H.},
  journal = {IEEE Control Systems Letters},
  volume = {9},
  pages = {949--954},
  year = {2025},
  doi = {10.1109/LCSYS.2025.3577236},
}

CDC

Adaptive Observers for Calibrating Immune Digital Twins in Viral Infections

Angel Rodriguez-Liñan, Juan E. Sereno, Griselda Quiroz-Compean, and 1 more author

In 64th IEEE Conference on Decision and Control (CDC), 2025

DOI Bib

@inproceedings{rodriguezlinan2025adaptive,
  title = {Adaptive Observers for Calibrating Immune Digital Twins in Viral Infections},
  author = {Rodriguez-Liñan, Angel and Sereno, Juan E. and Quiroz-Compean, Griselda and Hernandez-Vargas, Esteban A.},
  booktitle = {64th IEEE Conference on Decision and Control (CDC)},
  address = {Rio de Janeiro, Brazil},
  year = {2025},
  doi = {10.1109/CDC57313.2025.11312546},
}

ARC

Switched NMPC for epidemiological and social-economic control objectives in SIR-type systems

Juan E. Sereno, A. D’Jorge, Antonio Ferramosca, and 2 more authors

Annual Reviews in Control, 2023

DOI Bib

@article{sereno2023switched,
  title = {Switched {NMPC} for epidemiological and social-economic control objectives in {SIR}-type systems},
  author = {Sereno, Juan E. and D'Jorge, A. and Ferramosca, Antonio and Hernandez-Vargas, Esteban A. and González, Alejandro H.},
  journal = {Annual Reviews in Control},
  volume = {56},
  pages = {100901},
  year = {2023},
  doi = {10.1016/j.arcontrol.2023.100901},
}

Automatica

Minimizing the epidemic final size while containing the infected peak prevalence in SIR systems

Juan E. Sereno, A. Anderson, Antonio Ferramosca, and 2 more authors

Automatica, 2022

DOI Bib

@article{sereno2022minimizing,
  title = {Minimizing the epidemic final size while containing the infected peak prevalence in {SIR} systems},
  author = {Sereno, Juan E. and Anderson, A. and Ferramosca, Antonio and Hernandez-Vargas, Esteban A. and González, Alejandro H.},
  journal = {Automatica},
  volume = {144},
  pages = {110496},
  year = {2022},
  doi = {10.1016/j.automatica.2022.110496},
}